Compound in kale, cabbage and broccoli protects against bowel cancer

August 21, 2018  23:48

Kale, cabbage and broccoli protect against bowel cancer, new research suggests.

When green vegetables are digested a protein is activated that reduces gut inflammation and prevents the colon form of the disease, a study found today.

The protein, known as aryl hydrocarbon receptor (AhR), repairs damaged gut cells that would otherwise be unable to absorb nutrients or secrete protective mucus, the research adds. 

Damaged cells go on to divide uncontrollably, which can lead to bowel cancer, the study found. 

Study author Dr Gitta Stockinger, from the Francis Crick Institute, London, said: 'These findings are a cause for optimism; while we can't change the genetic factors that increase our risk of cancer, we can mitigate these risks by adopting a diet with plenty of vegetables.'

Green vegetables reduce tumours in cancer sufferers 

The researchers analysed genetically modified mice that could not produce or activate AhR in their guts.

The rodents developed gut inflammation that progressed to bowel cancer. 

Yet, the animals fed a diet rich in green vegetables developed neither inflammation nor cancer.

Lead author Dr Amina Metidji said: 'Interestingly, when mice whose cancer was already developing were switched to the [green vegetable]-enriched diet, they ended up with significantly fewer tumours which were also more benign.' 

'It's not just fibre in vegetables that reduces the risk of bowel cancer'

Professor Tim Key, from Cancer Research UK, who was not involved in the research, said: 'This study suggests it's not just the fibre in vegetables like broccoli and cabbage that help reduce the risk of bowel cancer, but also molecules found in these vegetables too.

'This adds to the evidence that a healthy diet, rich in vegetables, is important.' 

Dr Stockinger added: 'We often think of colon cancer as a disease promoted by a Western diet rich in fat and poor in vegetable content, and our results suggest a mechanism behind this observation. 

'Many vegetables produce chemicals that keep AhR stimulated in the gut. We found that AhR-promoting chemicals in the diet can correct defects caused by insufficient AhR stimulation. 

'This can restore cell differentiation, offering resistance to intestinal infections and preventing colon cancer.'

The researchers hope to analyse the effects of green vegetables on human colon cells in the lab and eventually in people.

Dr Stockinger added: 'There is very little literature on which vegetables are the most beneficial or why. 

'Now that we've demonstrated the mechanistic basis for this in mice, we're going to investigate these effects in human cells and people. In the meantime, there's certainly no harm in eating more vegetables!' 

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